BTC

Across TCGA patient cohorts, BTC protein abundance is significantly associated with the RNA expression of many other genes, with 630 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BTC-associated genes across cancer lineages are UQCRFS1P3, SPEF1, and WFDC2. Each is linked with BTC in more than 1 cancer types. Because this analysis shows association rather than direction, both BTC-to-partner and partner-to-BTC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BTC versus UQCRFS1P3 in UCEC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTC→partner) and Y-score (partner→BTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRFS1P3 →	+1.158	+0.568	.007	.006	3	2
LSCC	SPEF1 →	+1.218	+0.796	<.001	.001	3	1
LSCC	WFDC2 →	+3.067	+0.809	.001	.001	3	1
LSCC	EPPIN →	+0.391	+0.780	<.001	<.001	3	1
LSCC	FGD1 →	-0.552	-0.537	.003	.001	3	1
LSCC	TMC5 →	+2.340	+0.899	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

BTC vs UQCRFS1P3 — UCEC

Explore this scatter interactively →