BTC

Across TCGA pan-cancer cohorts, BTC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BTC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BTC RNA is repressed in tumor relative to normal tissue. In most cancer types BTC is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where BTC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.681	<.001	12	view →
HNSC	All	II,III,IV	−1.134	<.001	11	view →
LUSC	Male	III,IV	−2.662	<.001	8	view →
BLCA	Male	III,IV	−1.595	.008	8	view →
UCEC	All	II,III,IV	−1.442	.009	6	view →
COAD	All	All	−0.708	<.001	6	view →
BRCA	Female	All	−0.485	<.001	6	view →
CHOL	All	All	+2.017	<.001	5	view →
READ	All	All	−1.696	.003	5	view →
STAD	All	All	−1.174	.001	5	view →
KICH	All	All	−1.033	<.001	4	view →
KIRP	Male	All	−0.829	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BTC–KIRC

Open the KIRC breakdown →