BTC

Across TCGA patient cohorts, BTC mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTC-associated genes across cancer lineages are PCNA, MEK1, and Notch1. Each is linked with BTC in more than 1 cancer types. Because this analysis shows association rather than direction, both BTC-to-partner and partner-to-BTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BTC-low versus BTC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTC→partner) and Y-score (partner→BTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.251	+3.321	.026	.010	3	2
UCEC	MEK1 →	+0.438	+3.169	.022	.019	3	1
UCEC	Notch1 →	+0.235	+3.013	.001	.018	3	1
UCEC	YB-1_pS102 →	-0.221	-3.321	.022	.010	3	1
UCEC	AMPK_alpha →	-0.209	-3.000	.036	.036	2	1
UCEC	Cyclin-B1 →	+0.867	+3.000	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PCNA by BTC expression — UCEC

Explore this box plot interactively →