Across TCGA patient cohorts, BTBD6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD6-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and A-Raf_pS299. Each is linked with BTBD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD6-to-partner and partner-to-BTBD6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD6→partner) and Y-score (partner→BTBD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.148	+2.222	.015	.011	3	2
UCEC	EGFR_pY1068 →	-0.257	-3.169	.016	.018	3	1
UCEC	A-Raf_pS299 →	-0.153	-2.321	.002	.034	3	1
UCEC	JNK2 →	+0.228	+2.331	.006	.019	3	1
UCEC	Ku80 →	+0.207	+1.713	.039	.027	3	1
UCEC	MEK1 →	+0.323	+2.584	.037	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

BTBD6 survival (RNA) · tumor vs normal (RNA) · all BTBD6 data types