BSN

Across TCGA patient cohorts, BSN mutation is significantly associated with the RNA expression of many other genes, with 9,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BSN-associated genes across cancer lineages are FEN1, KIF23, and KPNA2. Each is linked with BSN in more than 6 cancer types. Because this analysis shows association rather than direction, both BSN-to-partner and partner-to-BSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by BSN-low versus BSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSN→partner) and Y-score (partner→BSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.415	+1.321	<.001	.001	3	7
STAD	KIF23 →	+0.527	+2.033	.006	.001	3	7
COAD	KPNA2 →	+0.293	+1.524	.005	.008	3	7
BLCA	CDC45 →	+0.816	+3.729	<.001	<.001	3	6
COAD	CCAR2 →	+0.292	+2.515	.004	<.001	3	6
STAD	RRM2 →	+0.752	+2.408	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,059 associations by consensus.

FEN1 by BSN expression — UCEC

Explore this box plot interactively →