BSN

Across TCGA patient cohorts, BSN mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. COAD shows the largest number of these associations.

The most reproducible BSN-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and ATM. Each is linked with BSN in more than 4 cancer types. Because this analysis shows association rather than direction, both BSN-to-partner and partner-to-BSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BSN-low versus BSN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSN→partner) and Y-score (partner→BSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.103	+2.815	<.001	<.001	3	5
STAD	4E-BP1 →	+0.256	+2.459	.013	.016	3	5
UCEC	ATM →	-0.398	-1.630	<.001	.002	3	5
COAD	mTOR_pS2448 →	-0.146	-2.790	.004	.002	3	4
STAD	PAI-1 →	+0.631	+2.584	.001	.009	3	4
BLCA	PCNA →	+0.218	+3.584	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

Caspase-7-cleavedD198 by BSN expression — COAD

Explore this box plot interactively →