BSN

Across TCGA cell cohorts, BSN mutation is significantly associated with the RNA expression of many other genes, with 1,178 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BSN-associated genes across cancer lineages are ZC3H10, TPGS2, and FEM1A. Each is linked with BSN in more than 2 cancer types. Because this analysis shows association rather than direction, both BSN-to-partner and partner-to-BSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3H10 grouped by BSN-low versus BSN-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSN→partner) and Y-score (partner→BSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZC3H10 →	+0.434	+3.106	.003	.004	3	3
LARGE_INTESTINE	TPGS2 →	+0.503	+3.409	.008	<.001	3	3
LARGE_INTESTINE	FEM1A →	+0.516	+1.956	<.001	.005	3	3
LARGE_INTESTINE	FBXO25 →	+0.623	+2.000	.005	.009	3	3
BLOOD_Leukemia	ASTN2 →	+0.593	+1.837	.001	.009	3	3
LARGE_INTESTINE	PAFAH2 →	+0.553	+3.321	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,178 associations by consensus.

ZC3H10 by BSN expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →