Across TCGA cell cohorts, BRWD1 mutation is significantly associated with the RNA expression of many other genes, with 1,069 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRWD1-associated genes across cancer lineages are SSX2IP, SENP3, and CNTROB. Each is linked with BRWD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRWD1-to-partner and partner-to-BRWD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRWD1→partner) and Y-score (partner→BRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSX2IP →	+0.842	+2.265	<.001	.001	3	3
LARGE_INTESTINE	SENP3 →	+0.464	+2.389	.002	.006	3	3
LARGE_INTESTINE	CNTROB →	+0.537	+3.321	.002	.003	3	3
LARGE_INTESTINE	PHF23 →	+0.494	+3.169	.003	.009	3	3
BREAST	IFNA5 →	+0.040	+2.618	<.001	.004	3	2
BREAST	S100Z →	+0.388	+2.807	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,069 associations by consensus.

Exploration

BRWD1 survival (RNA) · tumor vs normal (RNA) · all BRWD1 data types