BRWD1-AS2

Across TCGA pan-cancer cohorts, BRWD1-AS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BRWD1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BRWD1-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types BRWD1-AS2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where BRWD1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRWD1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.982	<.001	11	view →
KICH	Male	All	−1.830	<.001	10	view →
THCA	Male	All	−0.724	<.001	10	view →
LUSC	Female	All	+1.282	<.001	6	view →
LIHC	Male	All	+0.655	<.001	6	view →
BRCA	All	All	+0.312	<.001	6	view →
BLCA	Female	IV	+1.203	.009	3	view →
LUAD	All	All	+0.305	.001	3	view →
UCEC	All	All	+0.554	.016	2	view →
KIRP	All	All	−0.473	.008	2	view →
PRAD	All	All	+0.217	.032	2	view →
HNSC	Female	III,IV	−0.350	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BRWD1-AS2–KIRC

Open the KIRC breakdown →