BRSK2

Across TCGA cell cohorts, BRSK2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRSK2-associated genes across cancer lineages are IQCF6, ANKRD62, and UTF1. Each is linked with BRSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRSK2-to-partner and partner-to-BRSK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by BRSK2-low versus BRSK2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRSK2→partner) and Y-score (partner→BRSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IQCF6 →	+0.188	+3.990	<.001	.003	3	2
BLOOD_Leukemia	ANKRD62 →	+0.053	+2.926	.001	.009	3	2
LARGE_INTESTINE	UTF1 →	+0.012	+3.217	.001	.006	3	1
LARGE_INTESTINE	USP17L18 →	+0.006	+3.562	<.001	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
OVARY	GH2 →	+0.083	+3.938	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

IQCF6 by BRSK2 expression — OVARY

Explore this box plot interactively →