BRPF1

Across TCGA patient cohorts, BRPF1 mutation is significantly associated with the RNA expression of many other genes, with 2,489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRPF1-associated genes across cancer lineages are SOD1P1, AGAP3, and C15orf61. Each is linked with BRPF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRPF1-to-partner and partner-to-BRPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOD1P1 grouped by BRPF1-low versus BRPF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF1→partner) and Y-score (partner→BRPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SOD1P1 →	+0.207	+3.373	<.001	<.001	3	3
UCEC	AGAP3 →	+0.269	+1.740	.002	.002	3	3
UCEC	C15orf61 →	+0.349	+1.769	<.001	<.001	3	3
LUAD	RNU6-836P →	+1.145	+4.712	<.001	.007	3	3
LUAD	RNU6-206P →	+0.550	+5.912	<.001	.001	3	3
LUAD	OR6X1 →	+0.078	+5.912	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,489 associations by consensus.

SOD1P1 by BRPF1 expression — COAD

Explore this box plot interactively →