BROX

Across TCGA patient cohorts, BROX protein abundance is significantly associated with the RNA expression of many other genes, with 12,458 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BROX-associated genes across cancer lineages are COG2, PRUNE1, and BPNT1. Each is linked with BROX in more than 8 cancer types. Because this analysis shows association rather than direction, both BROX-to-partner and partner-to-BROX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BROX versus COG2 in BRCA, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BROX→partner) and Y-score (partner→BROX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COG2 →	+0.779	+0.453	<.001	<.001	3	9
LSCC	PRUNE1 →	+0.732	+0.503	<.001	<.001	3	9
UCEC	BPNT1 →	+0.840	+0.275	<.001	<.001	3	9
HNSC	SPRTN →	+0.702	+0.517	<.001	<.001	3	8
BRCA	ASH1L →	+0.703	+0.367	<.001	<.001	3	8
BRCA	RCOR3 →	+0.759	+0.386	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,458 associations by consensus.

BROX vs COG2 — BRCA

Explore this scatter interactively →