BROX

Across TCGA patient cohorts, BROX mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BROX-associated genes across cancer lineages are FASN, Smad3, and Bak. Each is linked with BROX in more than 1 cancer types. Because this analysis shows association rather than direction, both BROX-to-partner and partner-to-BROX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by BROX-low versus BROX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BROX→partner) and Y-score (partner→BROX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.490	+3.169	.001	.018	3	2
UCEC	Smad3 →	+0.132	+2.321	.029	.034	3	2
UCEC	Bak →	+0.276	+2.700	.006	.006	3	2
UCEC	EGFR_pY1068 →	-0.293	-3.087	.003	<.001	3	1
UCEC	eIF4G →	+0.270	+1.906	.030	.016	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.415	.035	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FASN by BROX expression — UCEC

Explore this box plot interactively →