BRMS1L

Across TCGA patient cohorts, BRMS1L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRMS1L-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with BRMS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both BRMS1L-to-partner and partner-to-BRMS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BRMS1L-low versus BRMS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRMS1L→partner) and Y-score (partner→BRMS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.305	-2.321	.003	.034	3	1
UCEC	EGFR →	-0.224	-1.807	<.001	.027	3	1
UCEC	eIF4E →	+0.173	+3.000	.047	.001	3	1
UCEC	FASN →	+0.433	+3.321	.007	.010	3	1
UCEC	ACC_pS79 →	+0.354	+1.807	.013	.027	3	1
UCEC	INPP4B →	-0.317	-2.459	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by BRMS1L expression — UCEC

Explore this box plot interactively →