BRMS1L

Across TCGA pan-cancer cohorts, BRMS1L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BRMS1L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRMS1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRMS1L is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where BRMS1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRMS1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.064	<.001	12	view →
THCA	Male	III,IV	−0.697	<.001	10	view →
KIRC	Male	II,III,IV	−0.590	<.001	9	view →
KICH	All	All	−0.600	<.001	8	view →
LIHC	All	All	+0.329	<.001	7	view →
KIRP	Male	All	−0.729	<.001	5	view →
LUSC	Male	All	+0.488	<.001	4	view →
BRCA	Female	All	−0.215	<.001	4	view →
LUAD	All	All	+0.277	.001	3	view →
CHOL	All	All	+1.047	<.001	2	view →
BLCA	Male	IV	−0.799	.002	2	view →
ESCA	Male	All	+0.666	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BRMS1L–HNSC

Open the HNSC breakdown →