BRIP1

Across TCGA pan-cancer cohorts, BRIP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BRIP1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BRIP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BRIP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, GBM, and LSCC are the cancer types where BRIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.683	.017	20	view →
GBM	OS	Median	All	0.941	0.665	.011	3	view →
LSCC	DFS	Median	All	0.979	0.859	.049	2	view →
HNSC	DFS	Median	III,IV	0.540	0.918	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BRIP1–UCEC (OS)

Open the UCEC breakdown →