BRIP1

Across TCGA pan-cancer cohorts, BRIP1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BRIP1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where BRIP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRIP1 is over-expressed in tumor.

BLCA, LUAD, and KIRP are the cancer types where BRIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.892	<.001	12	view →
LUAD	Male	III,IV	+2.113	<.001	11	view →
KIRP	All	IV	+1.364	<.001	11	view →
HNSC	Male	All	+1.166	<.001	11	view →
KIRC	Male	All	+0.867	<.001	11	view →
LUSC	Female	All	+2.359	<.001	9	view →
STAD	All	III,IV	+1.380	<.001	9	view →
LIHC	Male	All	+0.964	<.001	9	view →
COAD	Male	All	+0.941	<.001	9	view →
THCA	All	III,IV	+0.440	<.001	9	view →
UCEC	All	III,IV	+1.723	<.001	6	view →
BRCA	All	III,IV	+1.599	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BRIP1–BLCA

Open the BLCA breakdown →