BRIP1

Across TCGA cell cohorts, BRIP1 mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRIP1-associated genes across cancer lineages are OR10H5, LRRC55, and OR52E4. Each is linked with BRIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRIP1-to-partner and partner-to-BRIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H5 grouped by BRIP1-low versus BRIP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRIP1→partner) and Y-score (partner→BRIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10H5 →	+0.029	+3.185	.007	.006	3	2
BLOOD_Leukemia	LRRC55 →	+0.003	+3.185	<.001	.006	3	2
STOMACH	OR52E4 →	+0.216	+5.285	<.001	.003	3	2
LUNG_NSCLC_LUAD	WFDC10A →	+0.214	+2.536	.006	.007	3	2
OVARY	OR12D2 →	+0.051	+3.700	<.001	.005	3	2
LARGE_INTESTINE	ESCO1 →	+0.499	+3.064	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

OR10H5 by BRIP1 expression — BLOOD_Leukemia

Explore this box plot interactively →