BRINP3

Across TCGA patient cohorts, BRINP3 mutation is significantly associated with the RNA expression of many other genes, with 4,752 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP3-associated genes across cancer lineages are DENR, DRG1, and ERCC6L. Each is linked with BRINP3 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRINP3-to-partner and partner-to-BRINP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENR grouped by BRINP3-low versus BRINP3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP3→partner) and Y-score (partner→BRINP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DENR →	+0.294	+3.011	<.001	<.001	3	5
UCEC	DRG1 →	+0.253	+2.102	.002	<.001	3	4
STAD	ERCC6L →	+0.672	+2.733	.001	.003	3	4
UCEC	GAN →	+0.333	+1.638	<.001	<.001	3	4
LUAD	PIMREG →	+0.810	+1.727	<.001	.001	3	4
UCEC	EIF2S1 →	+0.456	+2.148	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,752 associations by consensus.

DENR by BRINP3 expression — LUAD

Explore this box plot interactively →