BRINP3

Across TCGA pan-cancer cohorts, BRINP3 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated BRINP3 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher BRINP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BRINP3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LGG show a favorable association.

KICH, ACC, and LIHC are the cancer types where BRINP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.601	1.000	<.001	95	view →
ACC	OS	Median	II,III,IV	0.706	0.932	<.001	33	view →
LIHC	DFS	Quartile	All	0.331	0.486	.002	30	view →
LUAD	OS	Quartile	II,III,IV	0.763	0.425	<.001	29	view →
BLCA	OS	Quartile	III,IV	0.192	0.429	.009	25	view →
LGG	DFS	Tertile	All	0.585	0.313	.006	19	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.399	.018	17	view →
MESO	OS	Tertile	IV	0.324	0.893	.014	17	view →
CESC	DFS	Tertile	All	0.632	0.787	.008	14	view →
KIRC	OS	Quartile	II,III,IV	0.595	0.752	.013	13	view →
LUSC	OS	Quartile	All	0.309	0.556	.002	13	view →
CHOL	DFS	Quartile	All	0.841	0.282	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

BRINP3–KICH (DFS)

Open the KICH breakdown →