BRINP3

Across TCGA patient cohorts, BRINP3 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP3-associated genes across cancer lineages are TFRC, ATM, and C-Raf. Each is linked with BRINP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRINP3-to-partner and partner-to-BRINP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by BRINP3-low versus BRINP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP3→partner) and Y-score (partner→BRINP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.490	+1.925	.001	.004	3	3
UCEC	ATM →	-0.622	-2.379	<.001	<.001	3	3
UCEC	C-Raf →	+0.131	+1.584	.001	.032	3	3
UCEC	Cyclin-B1 →	+0.507	+1.925	.001	.004	3	3
SKCM	MIG-6 →	+0.088	+1.025	.026	.029	3	3
STAD	FASN →	+0.434	+2.584	.012	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

TFRC by BRINP3 expression — UCEC

Explore this box plot interactively →