Across TCGA patient cohorts, BRINP2 mutation is significantly associated with the RNA expression of many other genes, with 5,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP2-associated genes across cancer lineages are CDCA2, EME1, and SPC24. Each is linked with BRINP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both BRINP2-to-partner and partner-to-BRINP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP2→partner) and Y-score (partner→BRINP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.813	+2.044	<.001	<.001	3	6
UCEC	EME1 →	+0.602	+2.290	<.001	<.001	3	5
UCEC	SPC24 →	+0.497	+1.632	.003	<.001	3	5
UCEC	ESCO2 →	+0.614	+2.271	<.001	<.001	3	5
UCEC	RAD51 →	+0.863	+2.055	<.001	<.001	3	5
UCEC	RAD54L →	+0.582	+2.584	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,594 associations by consensus.

Exploration

BRINP2 survival (RNA) · tumor vs normal (RNA) · all BRINP2 data types