Across TCGA patient cohorts, BRINP2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP2-associated genes across cancer lineages are 4E-BP1, ATM, and eIF4E. Each is linked with BRINP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRINP2-to-partner and partner-to-BRINP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP2→partner) and Y-score (partner→BRINP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.328	+2.467	<.001	.011	3	5
COAD	ATM →	-0.553	-2.450	.001	.020	3	4
UCEC	eIF4E →	+0.164	+2.713	.011	.003	3	4
UCEC	PCNA →	+0.245	+1.874	<.001	.002	3	3
UCEC	STAT3_pY705 →	-0.427	-2.137	<.001	<.001	3	3
UCEC	MEK1 →	+0.456	+2.536	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

BRINP2 survival (RNA) · tumor vs normal (RNA) · all BRINP2 data types