BRINP1

Across TCGA patient cohorts, BRINP1 mutation is significantly associated with the RNA expression of many other genes, with 7,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP1-associated genes across cancer lineages are SKA1, PTH1R, and ZMYND19. Each is linked with BRINP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRINP1-to-partner and partner-to-BRINP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by BRINP1-low versus BRINP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP1→partner) and Y-score (partner→BRINP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.681	+3.348	<.001	.004	3	5
UCEC	PTH1R →	-0.546	-1.652	.002	<.001	3	5
LUSC	ZMYND19 →	+0.426	+1.689	<.001	.006	3	5
UCEC	WDR62 →	+0.469	+2.606	<.001	<.001	3	5
UCEC	CDC45 →	+0.619	+1.562	<.001	<.001	3	5
LUAD	DTX4 →	-0.940	-2.999	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,084 associations by consensus.

SKA1 by BRINP1 expression — COAD

Explore this box plot interactively →