BRINP1

Across TCGA pan-cancer cohorts, BRINP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BRINP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BRINP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRINP1 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where BRINP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRINP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	+2.192	<.001	11	view →
HNSC	Male	III,IV	−0.830	<.001	7	view →
BRCA	Female	II,III,IV	−1.872	<.001	6	view →
KICH	Male	All	−1.420	<.001	5	view →
STAD	All	IV	−0.310	<.001	5	view →
BLCA	All	III,IV	−0.611	.020	4	view →
UCEC	All	IV	−0.510	.013	4	view →
CHOL	All	II,III,IV	−0.615	.004	2	view →
PRAD	All	All	−0.483	.006	2	view →
KIRC	Male	III,IV	−0.597	.047	1	view →
LIHC	Male	All	−0.251	.010	1	view →
COAD	Female	II,III,IV	−0.151	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BRINP1–THCA

Open the THCA breakdown →