BRINP1

Across TCGA patient cohorts, BRINP1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRINP1-associated genes across cancer lineages are ER-alpha, PCNA, and Di-Ras3. Each is linked with BRINP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both BRINP1-to-partner and partner-to-BRINP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by BRINP1-low versus BRINP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP1→partner) and Y-score (partner→BRINP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ER-alpha →	-0.088	-1.168	.048	.019	3	6
COAD	PCNA →	+0.259	+2.123	.007	.010	3	4
UCEC	Di-Ras3 →	-0.136	-1.830	.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.336	+2.815	<.001	.001	3	3
SKCM	ACC_pS79 →	+0.171	+1.144	.013	.001	3	3
SKCM	CD31 →	-0.105	-0.825	.005	.023	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

ER-alpha by BRINP1 expression — SKCM

Explore this box plot interactively →