BRINP1

Across TCGA cell cohorts, BRINP1 mutation is significantly associated with the RNA expression of many other genes, with 209 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRINP1-associated genes across cancer lineages are SKA1, H4C15, and DEFA4. Each is linked with BRINP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRINP1-to-partner and partner-to-BRINP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by BRINP1-low versus BRINP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP1→partner) and Y-score (partner→BRINP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SKA1 →	+0.778	+3.389	.003	.001	3	2
LARGE_INTESTINE	H4C15 →	-0.955	-3.541	.003	.001	3	2
LUNG_NSCLC_LUAD	DEFA4 →	+0.021	+4.078	<.001	.009	3	2
BLOOD_Myeloma	OR2AJ1 →	+0.013	+4.807	<.001	.006	3	1
OESOPHAGUS	MS4A2 →	+0.050	+4.857	<.001	<.001	3	1
LUNG_SCLC	SPANXN1 →	+0.519	+3.472	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 209 associations by consensus.

SKA1 by BRINP1 expression — LARGE_INTESTINE

Explore this box plot interactively →