BRINP1

Across TCGA cell cohorts, BRINP1 mutation is significantly associated with the mutation status of many other genes, with 4,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRINP1-associated genes across cancer lineages are PLEKHA5, BCL11A, and DISP3. Each is linked with BRINP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRINP1-to-partner and partner-to-BRINP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHA5 grouped by BRINP1-low versus BRINP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRINP1→partner) and Y-score (partner→BRINP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEKHA5 →	+1.989	+2.148	.003	.003	1	5
SKIN	BCL11A →	+2.445	+1.847	.005	.005	1	5
SKIN	DISP3 →	+1.860	+1.710	.005	.005	1	5
SOFT_TISSUE	COL3A1 →	+5.502	+5.502	.003	.003	1	5
OESOPHAGUS	PFAS →	+4.000	+3.087	.008	.008	1	4
OESOPHAGUS	PAPPA →	+2.830	+3.146	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

PLEKHA5 by BRINP1 expression — LARGE_INTESTINE

Explore this box plot interactively →