BRD9

Across TCGA patient cohorts, BRD9 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD9-associated genes across cancer lineages are PDCD4, ATM, and PREX1. Each is linked with BRD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD9-to-partner and partner-to-BRD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by BRD9-low versus BRD9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD9→partner) and Y-score (partner→BRD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.570	-1.797	<.001	.025	3	2
UCEC	ATM →	-0.667	-2.794	<.001	.002	3	2
SKCM	PREX1 →	-0.440	-3.321	.009	.009	3	1
SKCM	Src →	-0.291	-3.321	.014	.010	3	1
UCEC	EGFR_pY1068 →	-0.233	-1.847	.011	.008	3	1
UCEC	A-Raf_pS299 →	-0.145	-2.115	<.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

PDCD4 by BRD9 expression — UCEC

Explore this box plot interactively →