BRD8

Across TCGA patient cohorts, BRD8 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD8-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and c-Kit. Each is linked with BRD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRD8-to-partner and partner-to-BRD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BRD8-low versus BRD8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD8→partner) and Y-score (partner→BRD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.622	+2.824	<.001	.034	3	4
UCEC	ATM →	-0.598	-3.794	<.001	<.001	3	3
UCEC	c-Kit →	-0.185	-1.514	.020	.015	3	3
UCEC	MEK1 →	+0.393	+2.087	.001	.005	3	2
COAD	ASNS →	+0.443	+2.815	.041	.036	3	2
UCEC	ERK2 →	+0.179	+1.514	.006	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by BRD8 expression — COAD

Explore this box plot interactively →