BRD8

Across TCGA pan-cancer cohorts, BRD8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of BRD8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BRD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRD8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where BRD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.570	<.001	10	view →
LIHC	Female	II,III,IV	+1.295	<.001	9	view →
KIRC	All	All	+0.371	<.001	8	view →
CHOL	All	All	+2.363	<.001	5	view →
KICH	Female	All	−1.426	<.001	5	view →
LUAD	All	All	+0.331	<.001	4	view →
STAD	All	II,III,IV	+0.581	.014	3	view →
ESCA	All	II,III,IV	+0.985	.008	2	view →
BLCA	All	All	+0.397	.046	2	view →
READ	All	II,III,IV	+0.422	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

BRD8–COAD

Open the COAD breakdown →