BRD8

Across TCGA cell cohorts, BRD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,267 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRD8-associated GO terms across cancer lineages are Chromosome segregation, Centrosome cycle, and Regulation of DNA-templated transcription initiation. Each is linked with BRD8 in more than 18 cancer types. Because this analysis shows association rather than direction, both BRD8-to-partner and partner-to-BRD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome segregation grouped by BRD8-low versus BRD8-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD8→partner) and Y-score (partner→BRD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Chromosome segregation →	+0.085	+0.977	.003	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.097	+1.354	<.001	<.001	3	19
BREAST	Regulation of DNA-templated transcription initiation →	+0.065	+0.719	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome organization →	+0.078	+1.039	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.098	+1.208	<.001	<.001	3	19
STOMACH	Sister chromatid segregation →	+0.098	+0.727	<.001	.003	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,267 associations by consensus.

Chromosome segregation by BRD8 expression — BLOOD_Myeloma

Explore this box plot interactively →