BRD7

Across TCGA cell cohorts, BRD7 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRD7-associated genes across cancer lineages are PRMT5, TM9SF1, and SH3GL2. Each is linked with BRD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD7-to-partner and partner-to-BRD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRMT5 grouped by BRD7-low versus BRD7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD7→partner) and Y-score (partner→BRD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRMT5 →	+0.569	+3.364	.002	.002	3	1
LARGE_INTESTINE	TM9SF1 →	+0.578	+3.364	.009	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.123	+3.364	.001	.002	3	1
LARGE_INTESTINE	CASC3 →	+0.553	+3.169	.002	.009	3	1
LARGE_INTESTINE	BTBD7 →	+0.569	+3.451	.002	.002	3	1
LARGE_INTESTINE	HMGCS1 →	+0.914	+3.364	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

PRMT5 by BRD7 expression — LARGE_INTESTINE

Explore this box plot interactively →