BRD4

Across TCGA patient cohorts, BRD4 mutation is significantly associated with the RNA expression of many other genes, with 6,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD4-associated genes across cancer lineages are CNIH1, TIPIN, and ARF4. Each is linked with BRD4 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRD4-to-partner and partner-to-BRD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNIH1 grouped by BRD4-low versus BRD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD4→partner) and Y-score (partner→BRD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CNIH1 →	+0.506	+2.604	.001	<.001	3	5
COAD	TIPIN →	+0.623	+3.906	<.001	<.001	3	5
SKCM	ARF4 →	+0.530	+1.880	<.001	.001	3	5
SKCM	GON7 →	+0.471	+2.260	.001	.005	3	5
SKCM	UTP11 →	+0.609	+2.550	<.001	<.001	3	5
SKCM	PSMC6 →	+0.458	+3.610	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,020 associations by consensus.

CNIH1 by BRD4 expression — SKCM

Explore this box plot interactively →