BRD4

Across TCGA pan-cancer cohorts, BRD4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BRD4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRD4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, STAD, and COAD are the cancer types where BRD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.061	<.001	11	view →
STAD	Male	II,III,IV	+1.036	<.001	10	view →
COAD	Female	All	+0.612	<.001	10	view →
LIHC	Female	II,III,IV	+1.042	<.001	8	view →
LUSC	Male	II,III,IV	+0.773	<.001	8	view →
BRCA	All	II,III,IV	+0.338	<.001	6	view →
CHOL	Male	All	+1.663	<.001	5	view →
BLCA	All	All	+0.371	.005	5	view →
ESCA	All	All	+0.833	<.001	3	view →
THCA	All	All	−0.241	.002	3	view →
KIRP	All	IV	+0.975	.037	2	view →
READ	All	III,IV	+0.830	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BRD4–HNSC

Open the HNSC breakdown →