BRD4

Across TCGA cell cohorts, BRD4 mutation is significantly associated with the RNA expression of many other genes, with 749 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRD4-associated genes across cancer lineages are CCP110, WRAP73, and FBXW10. Each is linked with BRD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD4-to-partner and partner-to-BRD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCP110 grouped by BRD4-low versus BRD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD4→partner) and Y-score (partner→BRD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCP110 →	+0.546	+3.169	.006	.009	3	2
LARGE_INTESTINE	WRAP73 →	+0.432	+2.265	.007	.001	3	2
LARGE_INTESTINE	FBXW10 →	+0.166	+3.392	.001	.002	3	2
LARGE_INTESTINE	ZNF250 →	+0.359	+3.321	.007	.003	3	2
LARGE_INTESTINE	ZSWIM7 →	+0.663	+2.265	.001	.001	3	2
LARGE_INTESTINE	TEX13A →	+0.008	+1.836	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 749 associations by consensus.

CCP110 by BRD4 expression — LARGE_INTESTINE

Explore this box plot interactively →