BRD3OS

Across TCGA pan-cancer cohorts, BRD3OS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BRD3OS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRD3OS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRD3OS is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where BRD3OS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRD3OS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.995	<.001	9	view →
KICH	Female	II,III,IV	−2.142	<.001	8	view →
LIHC	Male	All	+0.618	<.001	8	view →
COAD	Female	II,III,IV	+0.884	<.001	7	view →
THCA	Male	II,III,IV	−0.676	<.001	7	view →
BRCA	All	II,III,IV	+0.240	.001	6	view →
CHOL	All	All	+2.128	<.001	3	view →
KIRP	All	II,III,IV	+0.488	.005	3	view →
BLCA	Male	IV	−1.447	<.001	2	view →
UCEC	All	All	−0.730	.003	2	view →
PRAD	All	All	−0.241	.007	2	view →
ESCA	All	All	+0.547	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BRD3OS–HNSC

Open the HNSC breakdown →