BRD3

Across TCGA patient cohorts, BRD3 mutation is significantly associated with the RNA expression of many other genes, with 4,103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD3-associated genes across cancer lineages are CENPU, AGPAT5, and PEF1. Each is linked with BRD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRD3-to-partner and partner-to-BRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by BRD3-low versus BRD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD3→partner) and Y-score (partner→BRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.652	+2.032	<.001	<.001	3	3
UCEC	AGPAT5 →	+0.421	+1.815	.002	.002	3	3
UCEC	PEF1 →	+0.204	+1.851	.006	.006	3	3
UCEC	BOLA3 →	+0.331	+1.551	<.001	<.001	3	3
UCEC	MOCS2 →	+0.451	+1.847	<.001	<.001	3	3
UCEC	POP5 →	+0.211	+2.885	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,103 associations by consensus.

CENPU by BRD3 expression — UCEC

Explore this box plot interactively →