BRD3

Across TCGA pan-cancer cohorts, BRD3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BRD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRD3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where BRD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.034	<.001	10	view →
COAD	Female	II,III,IV	+0.664	<.001	10	view →
THCA	All	II,III,IV	−0.720	<.001	9	view →
LIHC	Female	All	+0.777	<.001	7	view →
KIRC	All	II,III,IV	−0.452	<.001	6	view →
BRCA	All	II,III,IV	+0.362	<.001	6	view →
CHOL	Male	All	+1.841	<.001	5	view →
STAD	Male	II,III,IV	+1.061	.001	5	view →
KIRP	All	II,III,IV	+0.638	.012	3	view →
LUSC	All	All	+0.337	.014	3	view →
READ	All	III,IV	+0.554	<.001	2	view →
ESCA	Female	All	+0.546	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BRD3–HNSC

Open the HNSC breakdown →