BRD3

Across TCGA cell cohorts, BRD3 mutation is significantly associated with the RNA expression of many other genes, with 1,731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRD3-associated genes across cancer lineages are IQCF3, FUT5, and ATP1A4. Each is linked with BRD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRD3-to-partner and partner-to-BRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF3 grouped by BRD3-low versus BRD3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD3→partner) and Y-score (partner→BRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IQCF3 →	+0.078	+4.491	<.001	.003	3	3
BLOOD_Leukemia	FUT5 →	+0.240	+3.944	<.001	.001	3	2
BLOOD_Leukemia	ATP1A4 →	+0.346	+3.594	.004	.007	3	2
CNS	LRIT1 →	+0.759	+4.044	<.001	.003	3	2
LARGE_INTESTINE	FAM160A1 →	+0.856	+2.125	<.001	.004	3	2
BLOOD_Leukemia	OR1J2 →	+0.058	+2.991	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,731 associations by consensus.

IQCF3 by BRD3 expression — PANCREAS

Explore this box plot interactively →