BRD1

Across TCGA cell cohorts, BRD1 mutation is significantly associated with the RNA expression of many other genes, with 985 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRD1-associated genes across cancer lineages are KLRB1, ASIP, and FAM149A. Each is linked with BRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD1-to-partner and partner-to-BRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRB1 grouped by BRD1-low versus BRD1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD1→partner) and Y-score (partner→BRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KLRB1 →	+0.046	+3.784	<.001	.006	3	2
BLOOD_Leukemia	ASIP →	+0.323	+3.215	.005	.005	3	2
BLOOD_Leukemia	FAM149A →	+1.189	+3.309	<.001	.006	3	2
BLOOD_Leukemia	CAPN7 →	+0.550	+3.199	.001	.007	3	2
BLOOD_Leukemia	GATAD2B →	+0.671	+3.199	.001	.007	3	2
BLOOD_Leukemia	PXYLP1 →	+1.673	+3.199	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 985 associations by consensus.

KLRB1 by BRD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →