Across TCGA patient cohorts, BRCC3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,960 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BRCC3-associated genes across cancer lineages are FAM72D, SYT9, and SEC23IP. Each is linked with BRCC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRCC3-to-partner and partner-to-BRCC3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCC3→partner) and Y-score (partner→BRCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM72D →	-1.065	-0.566	<.001	<.001	2	4
BRCA	SYT9 →	+1.408	+0.160	<.001	<.001	3	3
BRCA	SEC23IP →	+0.412	+0.142	.001	<.001	3	3
UCEC	ATE1 →	+0.410	+0.142	<.001	<.001	3	3
GBM	MICU1 →	+0.476	+0.171	<.001	<.001	3	3
UCEC	ANXA7 →	+0.565	+0.204	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,960 associations by consensus.

Exploration

BRCC3 survival (RNA) · tumor vs normal (RNA) · all BRCC3 data types