BRCA1

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BRCA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 24,669 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BRCA1-associated proteins across cancer lineages are TOP2A, PRIM2, and TOP2A_S1106. Each is linked with BRCA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both BRCA1-to-partner and partner-to-BRCA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRCA1 versus TOP2A in LUAD, with a Pearson correlation of 0.81.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA1→partner) and Y-score (partner→BRCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADTOP2A →+1.287+1.204<.001<.001310
LUADPRIM2 →+0.472+0.818<.001<.00139
LUADTOP2A_S1106 →+1.506+1.155<.001<.00139
LUADNUF2_S247 →+1.260+1.079<.001<.00139
LUADMCM2 →+0.910+1.220<.001<.00139
LUADMCM2_S139 →+1.160+1.109<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 24,669 associations by consensus.

BRCA1 vs TOP2A — LUAD

Per-sample scatter of BRCA1 vs TOP2A in LUAD (Pearson r = 0.81).

Explore this scatter interactively →

Exploration