BRAP

Across TCGA patient cohorts, BRAP mutation is significantly associated with the RNA expression of many other genes, with 882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRAP-associated genes across cancer lineages are RNU6-222P, SNRPGP20, and SNORA36C. Each is linked with BRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both BRAP-to-partner and partner-to-BRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-222P grouped by BRAP-low versus BRAP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAP→partner) and Y-score (partner→BRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-222P →	+0.205	+4.683	.002	.005	3	2
BLCA	SNRPGP20 →	+0.107	+3.411	.005	.005	3	2
BLCA	SNORA36C →	+0.173	+3.411	<.001	.005	3	2
SKCM	GOLGA6D →	+0.014	+3.449	.002	.002	3	2
UCEC	MOCS2 →	+0.410	+1.947	.002	.003	3	2
UCEC	ATG4A →	+0.429	+1.925	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

RNU6-222P by BRAP expression — BRCA

Explore this box plot interactively →