BRAP

Across TCGA pan-cancer cohorts, BRAP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BRAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRAP is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where BRAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.732	<.001	11	view →
KIRC	All	All	+0.351	<.001	11	view →
BLCA	Female	III,IV	+0.627	<.001	10	view →
LIHC	Female	II,III,IV	+0.909	<.001	9	view →
STAD	All	II,III,IV	+0.670	<.001	9	view →
LUSC	Male	II,III,IV	+0.573	<.001	9	view →
KIRP	All	II,III,IV	+0.606	.001	7	view →
COAD	Male	All	+0.297	<.001	7	view →
THCA	Male	II,III,IV	−0.326	.010	6	view →
BRCA	All	II,III,IV	+0.138	.008	6	view →
CHOL	Male	All	+1.724	<.001	5	view →
LUAD	Male	All	+0.356	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BRAP–HNSC

Open the HNSC breakdown →