BRAP

Across TCGA patient cohorts, BRAP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRAP-associated genes across cancer lineages are ASNS, ATM, and 14-3-3_beta. Each is linked with BRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both BRAP-to-partner and partner-to-BRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by BRAP-low versus BRAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAP→partner) and Y-score (partner→BRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.509	+2.459	<.001	.018	3	2
UCEC	ATM →	-0.566	-3.584	.002	.002	3	2
UCEC	14-3-3_beta →	-0.128	-2.432	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.244	-1.807	.018	.027	3	1
UCEC	ERK2 →	+0.248	+3.459	.001	.005	3	1
UCEC	GATA6 →	-0.160	-2.215	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by BRAP expression — UCEC

Explore this box plot interactively →