BRAP

Across TCGA cell cohorts, BRAP mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRAP-associated genes across cancer lineages are UNC45B, OR8B12, and OR8B4. Each is linked with BRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both BRAP-to-partner and partner-to-BRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC45B grouped by BRAP-low versus BRAP-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAP→partner) and Y-score (partner→BRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UNC45B →	+0.006	+5.000	<.001	.006	3	1
OVARY	OR8B12 →	+0.023	+5.807	<.001	.001	3	1
OVARY	OR8B4 →	+0.020	+5.807	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.872	+3.160	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.112	+2.793	<.001	.002	3	1
LARGE_INTESTINE	PPA2 →	+0.744	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

UNC45B by BRAP expression — PANCREAS

Explore this box plot interactively →