BPTF

Across TCGA patient cohorts, BPTF RNA expression is significantly associated with the protein abundance of many other proteins, with 18,051 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BPTF-associated proteins across cancer lineages are SF3B3, SIN3A, and GTF3C2. Each is linked with BPTF in more than 6 cancer types. Because this analysis shows association rather than direction, both BPTF-to-partner and partner-to-BPTF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BPTF versus SF3B3 in GBM, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BPTF→partner) and Y-score (partner→BPTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B3 →	+0.238	+0.386	<.001	<.001	3	7
HNSC	SIN3A →	+0.236	+0.765	<.001	<.001	3	6
HNSC	GTF3C2 →	+0.283	+0.474	<.001	<.001	3	6
HNSC	HCFC1 →	+0.272	+0.462	<.001	<.001	3	6
HNSC	HDAC2 →	+0.340	+0.669	<.001	<.001	3	6
GBM	HNRNPL →	+0.199	+0.362	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,051 associations by consensus.

BPTF vs SF3B3 — GBM

Explore this scatter interactively →