BPNT1

Across TCGA patient cohorts, BPNT1 mutation is significantly associated with the RNA expression of many other genes, with 2,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPNT1-associated genes across cancer lineages are LIN7C, COX15, and NOCT. Each is linked with BPNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPNT1-to-partner and partner-to-BPNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by BPNT1-low versus BPNT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPNT1→partner) and Y-score (partner→BPNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.548	+3.628	.002	.001	3	2
UCEC	COX15 →	+0.424	+3.329	.002	.005	3	2
UCEC	NOCT →	+0.620	+2.815	<.001	.001	3	2
UCEC	TWF1 →	+0.611	+2.246	.006	.005	3	2
UCEC	EIF4E →	+0.520	+3.600	<.001	.001	3	2
UCEC	HOMER1 →	+0.837	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,629 associations by consensus.

LIN7C by BPNT1 expression — UCEC

Explore this box plot interactively →