Across TCGA cell cohorts, BPIFC mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible BPIFC-associated genes across cancer lineages are TBL1Y, TMEM61, and AQP12A. Each is linked with BPIFC in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFC-to-partner and partner-to-BPIFC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFC→partner) and Y-score (partner→BPIFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
BLOOD_Myeloma	TMEM61 →	+1.126	+4.807	.001	.006	3	1
BLOOD_Myeloma	AQP12A →	+0.076	+4.807	<.001	.006	3	1
BLOOD_Myeloma	ADGRA1 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GALP →	+0.046	+4.807	<.001	.006	3	1
LUNG_SCLC	S100G →	+0.120	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

BPIFC survival (RNA) · tumor vs normal (RNA) · all BPIFC data types